Non-Technical Summary of Glyconutrients Research
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A nontechnical summary, prepared by TC North, Ph.D., CEO of Catalyst Consulting Group, of the presentation by H. Reg McDaniel, M.D., medical director, Manna Relief Ministries A professional abstract presented at the Third National Conference New Initiatives in the Prevention and Intervention of Fetal Alcohol Syndrome/Fetal Alcohol Effects for Aboriginal Peoples of Canada
May 21-22, 2003 Vancouver, BC
This summary educates the non-medical independent Mannatech associate about helping people with the information in Dr. McDaniel’s presentation. It also provides the basics to accurately give health and medical professional’s information from a nontechnical perspective.
The information in this paper is factual, but it does not represent evidence-based science. It is beginning science. More glyconutrients research will be necessary to substantiate what is presented here.
Individuals have reported that the addition of a “gummy bear-like” food made with vine-ripened fruits and vegetables and certain sugars (that are now termed necessary sugars) improved the behavior of children with attention deficit disorder/hyperactive syndrome. This led to a small, but thorough, study of these kids, which again showed positive results. A host of other reports of children with a variety of medical challenges including autism, asthma, infections and allergies indicated improvement in their health when taking these micronutrients. Five fetal alcohol syndrome (FAS) children had significant improvement using these micronutrients, and in one case, a child’s IQ increased from below 80 to 112.
Early Glyconutrients Research
A scientific team from Carrington Laboratories discovered that the active ingredient in aloe vera is a simple sugar called mannose. Biochemistry studies found that the critical step in making human cells requires several molecules of mannose. Thus mannose is not used for energy but for constructing healthy cells. This led to discovering additional simple sugars that are necessary for building the cells. This combination of eight sugars used in cell synthesis was patented and named Ambrotose.
In a study of FAS children who took Ambrotose for 12 to 36 months, 67 percent showed improvement in FAS symptoms. This improvement in behavior and performance in school and at home reported by parents provides an optimistic potential for the future of these children.
Another child, who started taking micronutrients at 18 months old, has improved 90 percent to 95 percent since beginning use of Ambrotose.
This anecdotal data gives us hope about the benefits of Ambrotose for FAS children. However, more sophisticated studies are needed.
How Such Improvements in FAS Children Are Possible
These improvements could be the result of two processes involving the sugars in Ambrotose. First, it provides nutrition that builds healthy cells (healthy glycoproteins and glycolipids) and second, Ambrotose may stimulate the development of stem cells that could potentially build new cells in the brain. If this happens, it would provide an amazing healing potential for many conditions that have caused brain and/or nerve damage.
Humans need almost 100 trace elements, necessary sugars, proteins and fats to make one healthy cell. If any of the raw materials are missing, the cell is incomplete and will not function as an optimum cell. This often leads to feelings of fatigue, inability to sleep and sometimes memory loss and/or depression.
More and more evidence shows that there is a correlation between many of the chronic diseases that are increasing in this country and the lack of these micronutrients in the diet. When these nutrients are added in the diet, health is restored in some people.
The immune system is an example of the importance of the necessary sugars. The necessary sugars combine with protein on the outside of the immune system cells to form a glycoprotein. These glycoproteins allow the immune system to recognize foreign particles (e.g., viruses and bacteria) and to identify one’s body as something not to be attacked (all the 80+ autoimmune diseases are the result of the immune system’s attacking a part of one’s body).
When provided with glyconutrients and other micronutrients, improvements in function have been seen in children suffering from toxic damage to the brain caused by maternal alcohol intake (FAS). Some adults have had reversal of presumed permanent liver and neurological damage.
Reduced glutathione is a master antioxidant in cells and protects cell membranes from DNA damage. Glyconutrients have increased reduced glutathione inside the cell by 50 percent in 300 seconds in liver cells. This is important to protect and optimize the function of brain cells, especially when injured by the metabolic products of alcohol.
Stem cells have the ability to regenerate any other cell in the body. Thus a stem cell can become a neuron, a liver cell, a brain cell, a fingernail cell, etc.
On February 19, 2003, a remarkable article in The Journal of the American Medical Association (JAMA) on research from Johns Hopkins Medical School reported for the first time that donor stem cells crossed the blood brain barrier and became neurons in the recipient’s brain. This is an important finding because neurons are the most highly advanced functional cells in the body; they control all brain and muscle functions. This is a recent revolutionary discovery about the potential to repair and regenerate the human brain.
Early research on glyconutrients (the necessary sugars) suggests that by adding glyconutrients to the human diet, there is an increase in production in one’s bone marrow stem cell production.
Until the JAMA article, Dr. McDaniel’s science team had not been unable to explain how adults with Alzheimer’s, Parkinson’s, and Huntington’s and children with cerebral palsy, leukodystrophy, Down syndrome, autism and FAS experience restorations in brain function with the addition of glyconutrients and other micronutrients to their diet.
Prior to this knowledge in 2003 from JAMA, there was no reasonable scientific explanation of how the many individuals with presumed permanent brain injury from strokes, trauma or neurodegenerative disorders could heal and regain lost central nervous system function that physicians and scientists had regarded as permanent and irreversible.
Our new understanding of glyconutrients stimulating the development of one’s bone marrow stem cells, which have the capacity to develop into any cell the body needs, provides us with a scientific understanding of how such unparalleled restorations of brain function can be induced by dietary supplementation of glyconutrients.
Important Scientific Questions
Do new or regenerated neurons in the brain that develop from stem cells function correctly? Consider the following case studies:
In a case history in 2002, a child who had been in a coma for three years began ingesting micronutrients. Within five days, his brain function started changing. There are also four other case histories in which parents gave these micronutrients to their children to awaken them from long-term comas. These case histories have created so much hope and interest that the pediatric neurologists who work with over 200 hopeless children in comas are beginning a pilot study on 20 of these children to better determine the potential affects of these micronutrients.
In another case study, a 6-year-old boy had been in a deep, unresponsive coma for three years. His EEG, which shows brain activity, was virtually flat in all parts of his brain before micronutrients. After six months of micronutrient supplementation, he had a phenomenal increase in activity in all parts of his brain. This increase in brain activity indicates restored neurological (brain) function associated with micronutrient dietary intake.
Another case history involves Sara, a premature FAS child with heart defects and cerebral palsy at birth. Sara’s adoptive mother began giving her micronutrients daily by rubbing a cream with glyconutrients on her entire body in the premature nursery. When Sara could drink from a bottle, the adoptive mother gave her glyconutrients followed by all of Mannatech’s micronutrients in a bottle. When evaluated by pediatric specialists at 4 years old, she no longer had any evidence of FAS or cerebral palsy, and her heart developed normally and required no surgery.
Photographs of Sara show that at birth her face displayed the characteristics of a child with severe FAS. By age four her face had lost all FAS characteristics and appeared “normal” and her IQ changed from less than 80 to over 100. This is an unprecedented change for an FAS child.
These individual case history reports do not provide scientific proof. However, they do give us hope and are leading to additional studies.
Dr. McDaniel’s science team has noted many unexplainable restorations of function of the central nervous system, pancreas cells, lung, kidney, and heart that defy explanation. The team has seen changes in people of all ages, including infants, children, teenagers, adults and some quite elderly, who were thought to be in irreversible health situations. The discovery of the stimulation of stem cell development in one’s body can take place within one week of adding glyconutrients. This may explain all of these medically impossible changes.
The potential benefits for supporting health recovery by using micronutrients are beyond material measure.
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